Haliclocyclin C, a New Monomeric 3-Alkyl Pyridinium Alkaloid from the Arctic Marine Sponge Haliclona viscosa

In recent years, a number of novel 3-alkyl pyridinium alkaloids were identified from the crude extract of the Arctic marine sponge Haliclona viscosa [1 – 5]. The material available from this sponge was limited by the small size of the individuals, their slow growth rate and the effort to sample substainably in the Arctic ecosystem. A new refinement of the spectroscopic methods led to improved resolution of the compound peaks in HPLC experiments and consequently also in the coupled mass spectrometric analyses. As a result, we were able to identify a new monomeric 3-alkyl pyridinium alkaloid (1, Scheme 1) by HPLC-HRMS experiments.